What are cannabinoids?

Cannabinoids are the naturally occurring chemical compounds found in the cannabis plant. Cannabinoids are responsible, in part, for the wide array of medicinal and psychoactive effects cannabis provides. There are over 110 known cannabinoids so far with studies continuing to reveal the complex molecular structures of the cannabis plant.

Cannabinoids interact with human physiology through the endocannabinoid system (ECS), the set of receptors that function to regulate health and promote homeostasis throughout the body, you can read more about the ECS on our website here. The ECS has two primary receptors, the CB1 and CB2. The CB1 receptor binds primarily to the brain and nervous system, while the CB2 receptor interacts largely with the immune system. The cannabis plant relies on cannabinoids binding to these receptors to produce the array of potential benefits and effects. Each cannabinoid holds unique characteristics of their own that are worth examining in order to maximize the desired effects from medical cannabis. Today we are looking at the cannabinoid THCV or Tetrahydrocannabivarin.

What is THCV?

The cannabinoid Tetrahydrocannabivarin (THCV) holds a potential for potent psychoactive effects along with many medicinal benefits. Similar in chemical composition to Tetrahydrocannabinol (THC), THCV is thought to act as an antagonist to some of the effects of THC when found in small amounts, while possibly increasing them in higher doses. Strains or products with high levels of THCV may result in a stimulating, clear headed, almost psychedelic type of energetic high that is typically found to be shorter in duration.

THCV displays appetite suppressing effects, which make it a potential weight loss aid and is possibly beneficial for diabetics by aiding in the regulation of blood glucose levels. THCV may also play a role in protecting bone health, which could help osteoporosis. THCV also displays anticonvulsant properties that may help with epilepsy and neurodegenerative-related disorders. THCV show potential to combat anxiety and panic attacks, with promising use for those who suffer from Post-traumatic Stress Disorder (PTSD). Additionally, THCV is also considered an antioxidant and a potent anti-inflammatory agent.

How does it work?

THCV binds with both the CB1 and CB2 receptors in the endocannabinoid system. However, the binding process will differ significantly depending on dosage. Low doses appear to inhibit the psychoactive effects produced by THC, indicating THCV shows antagonistic properties upon interaction with the ECS. When higher doses are consumed, THCV converts to an agonist of both receptors and exhibits behavior similar to that of THC, resulting in the enhanced euphoric effects.

THCV is becoming one of the most researched cannabinoids due to its potential health benefits. THCV displays potential ability to alter the psychoactive sensation cannabis gives as well as having the versatility to interact with the ECS. While found in small amounts in most cannabis strains, THCV has been found to be more abundant in Sativas – Ask any of our trained and knowledgeable GreenLeaf Solutions budtenders any questions you may have concerning cannabis.

The Science

A study from May 2010 highlighted the anti-inflammatory effects of THCV. The anticonvulsant properties of THCV were the subject of an August 2010 study with promising findings. An August 2011 study focused on the antioxidant neuroprotective properties of THCV to potentially delay the progression of Parkinson’s Disease and provide symptomatic relief. A May 2013 study examined THCV to potentially reduce insulin sensitivity, making this cannabinoid a possible agent to regulate glucose levels. THCV’s ability to act as antipsychotic was the subject of a 2015 study that concluded THCV has therapeutic potential to treat schizophrenia. A study from October 2016 showed THCV could possibly aid with obesity-associated glucose intolerance.

Bartlesville’s Only Physician Owned Cannabis Dispensary

GreenLeaf Solutions is Bartlesville’s top rated cannabis dispensary and the only dispensary in NE Oklahoma that is owned and operated by licensed physicians. We take great pride in our award-winning cannabis flower, highest quality products, and the absolute best patient service. Come see why we’re Bartlesville’s best cannabis dispensary!

Our doors are open Monday through Friday from 10:00am to 7:00pm and Saturday from 10:00am to 4:00pm. Call us anytime as well at 918-214-8775.

During the COVID-19 pandemic we are taking orders over the phone and delivering curbside. Call ahead or call when you pull in! We are here to serve our patients!


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